Microneedling, Exosomes & PDRN in Bakersfield

Microneedling is a popular cosmetic procedure that involves using tiny needles to create superficial punctures in the skin. This stimulates the body's natural healing response and triggers the production of collagen and elastin, essential proteins that improve skin texture and appearance. 

During a microneedling session, our nurse practitioner will numb your face with a Lidocaine 5% cream 10 to 15 minutes before the procedure. She then uses a specialized FDA-cleared device equipped with multiple small needles to create controlled micro-injuries on the skin's surface. These micro-injuries prompt the skin to kickstart its natural repair process, increasing collagen and elastin production. The newly formed collagen helps to rejuvenate the skin, reducing the appearance of wrinkles, scars, and other skin imperfections. The needle's depth depends on the goal. For melasma, the needle goes superficial; skin rejuvenation and acne scars may go deeper into the dermis. 

The procedure is relatively non-invasive, with minimal downtime and side effects compared to more aggressive treatments like chemical peels or laser therapy. However, it may cause temporary redness, swelling, or sensitivity in the treated area. 

Multiple studies have shown microneedling's efficacy in improving various skin conditions, such as acne scars, fine lines, and uneven skin tone. In a study published in the Journal of Cosmetic Dermatology, researchers found that microneedling significantly improved acne scars after multiple sessions. Another study in Dermatologic Surgery showed a noticeable reduction in wrinkles and skin laxity with microneedling treatments. 

In conclusion, microneedling is a safe and effective cosmetic procedure that can help improve skin texture, tone, and overall appearance. By stimulating collagen production through controlled micro-injuries, microneedling offers a non-invasive solution for various skin concerns. 

References:

da Silva, S.J., Alster, T.S., Graham, P.M. (2018). Microneedling: a review and practical guide.  doi: 10.1097/DSS.0000000000001248. PMID: 28796657

 da Silva, S. J., & Cé, R.  (2025). Therapeutic potential of polydeoxyribonucleotide (PDRN) in dermatology and aesthetic medicine: Molecular mechanisms and anti-aging applications. Centro Universitário Avantis (UNIAVAN), Department of Biomedical Sciences. 

Yun W.J., Kim, D., Kim, E.H. (2022). Exosome-Enriched Adipose-Derived Stem Cells for Skin Regeneration. Stem Cells Int. doi: 10.1155/2022/4091486.

Kim, J. Y., Song, S. H., Kim, K. L., Ko, J. J., Im, G. H., Kim, J., Kim, H. C., Kim, K., Machino-Ohtsuka, T., Yoshida, M., Lee, S. C., & Suh, W. (2018). Exosomes secreted from induced pluripotent stem cell-derived mesenchymal stem cells accelerate skin cell proliferation. International Journal of Molecular Sciences, 19(2), 311. https://doi.org/10.3390/ijms19020311

What is Microneedling?

Microneedling is a skin treatment that uses tiny needles to stimulate collagen production and improve skin texture, tone, and overall appearance.

What does microneedling help with?

Microneedling can improve:

• Fine lines and wrinkles 
• Acne scars 
• Enlarged pores 
• Uneven skin texture 
• Dull or dehydrated skin 

What are exosomes for skin?

Exosomes are advanced regenerative ingredients that help repair skin, boost collagen, and improve signs of aging.

What is PDRN skin treatment?

PDRN (polydeoxyribonucleotide) is a skin booster that hydrates, heals, and strengthens the skin barrier.

What is the difference between exosomes and PDRN?

• Exosomes: Best for anti-aging and collagen stimulation 
• PDRN: Best for hydration, healing, and sensitive skin 

Which treatment is best for dry skin?

PDRN is ideal for dry or sensitive skin because it improves hydration and supports skin repair.

Which treatment is best for anti-aging?

Exosomes are ideal for anti-aging because they boost collagen and improve skin elasticity.

Is microneedling with exosomes or PDRN safe?

Yes, when performed by a trained provider, microneedling with exosomes or PDRN is safe for most skin types.

How long is the downtime after microneedling?

Most clients' experience redness for 24–72 or few hours with minimal downtime.

When will I see results?

You may notice a glow in a few days, with full results developing over 4–6 weeks.

How many treatments do I need?

Most clients need 3–4 treatments spaced about 4–6 weeks apart for best results.

Can microneedling improve skin hydration? 

Yes, especially when combined with PDRN or hydrating serums, microneedling can significantly improve skin hydration.

Who should avoid microneedling? 

Avoid treatment if you have active acne, skin infection, or open wounds in the treatment area.

Why choose us for microneedling in Bakersfield?

We provide customized, medical grade microneedling treatments in Bakersfield using advanced techniques with exosomes and PDRN to deliver natural, glowing results. Our skilled and certified nurse practitioner performs the procedure. 

Personalized skin treatments in Bakersfield designed for healthy, radiant skin.